Cart
sales@molnova.com
Cortexolone 17 alpha-propionate
CAS No. 19608-29-8
Cortexolone 17 alpha-propionate( Cortexolone 17α-propionate | CB-03-01 | Clascoterone )
Catalog No. M13075 CAS No. 19608-29-8
Cortexolone 17 alpha-propionate (CB-03-01, Clascoterone) is a topical and peripherally selective androgen antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 28 | In Stock |
|
| 10MG | 40 | In Stock |
|
| 25MG | 65 | In Stock |
|
| 50MG | 87 | In Stock |
|
| 100MG | 140 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCortexolone 17 alpha-propionate
-
NoteResearch use only, not for human use.
-
Brief DescriptionCortexolone 17 alpha-propionate (CB-03-01, Clascoterone) is a topical and peripherally selective androgen antagonist.
-
DescriptionCortexolone 17 alpha-propionate (CB-03-01, Clascoterone) is a topical and peripherally selective androgen antagonist, displays a strong local antiandrogenic activity in hamster's flank organ test, does not exhibit antiandrogenic activity after subcutaneous injection in vivo.Other Indication Phase 3 Clinical(In Vivo):Clascoterone is a new potent topical antiandrogen potentially useful in acne vulgaris. Clascoterone 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.
-
In Vitro——
-
In VivoClascoterone is a new potent topical antiandrogen potentially useful in acne vulgaris. Clascoterone 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.
-
SynonymsCortexolone 17α-propionate | CB-03-01 | Clascoterone
-
PathwayEndocrinology/Hormones
-
TargetAndrogen Receptor (AR)
-
RecptorAndrogenReceptor
-
Research AreaOther Indications
-
IndicationOther Disease
Chemical Information
-
CAS Number19608-29-8
-
Formula Weight402.53
-
Molecular FormulaC24H34O5
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESCCC(O[C@]1(C(CO)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O
-
Chemical NamePregn-4-ene-3,20-dione, 21-hydroxy-17-(1-oxopropoxy)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Rolapitant hydrochlo...
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity.
-
2,2,5,7,8-Pentamethy...
2,2,5,7,8-Pentamethyl-6-Chromanol is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.
-
Dimethylcurcumin
Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion.Dimethylcurcumin is able to degrade fAR and AR3 in a dose-dependent manner in various human PCa cells. Dimethylcurcumin can also effectively suppress AR-targeted genes in CWR22Rv1-fARKD cells.
